Transcriptional co-factors and hepatic energy metabolism
نویسندگان
چکیده
منابع مشابه
Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP.
The liver is a central organ that controls systemic energy homeostasis and nutrient metabolism. Dietary carbohydrates and lipids, and fatty acids derived from adipose tissue are delivered to the liver, and utilized for gluconeogenesis, lipogenesis, and ketogenesis, which are tightly regulated by hormonal and neural signals. Hepatic lipogenesis is activated primarily by insulin that is secreted ...
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A major cause of fasting hyperglycemia in diabetes mellitus is unregulated hepatic glucose production (HGP). Insulin suppresses HGP by phosphorylating CBP and disassembling the CREB-CBP complex from gluconeogenic genes. p300 is closely related to CBP; but in contrast to CBP, p300 binds constitutively to CREB due to the absence of phosphorylation site found in CBP. In a phosphorylation-competent...
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Retinoic acid (RA), an active metabolite of vitamin A (VA), is important for many physiological processes including energy metabolism. This is mainly achieved through RA-regulated gene expression in metabolically active cells. RA regulates gene expression mainly through the activation of two subfamilies in the nuclear receptor superfamily, retinoic acid receptors (RARs) and retinoid X receptors...
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The purpose of this paper is to integrate lipid catabolism, ketogenesis and acid-base balance during starvation. The calculations made in this presentation may be approximate, but the values give useful information. Emphasis is directed toward hydrogen (hydronium and hydride) transfer during the hyperketonaemic state of starvation, and a special role is assigned to /%hydroxybutyrate as a regula...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2011
ISSN: 0303-7207
DOI: 10.1016/j.mce.2010.11.020